I don't think you can...because whether a monocyte become a M1 or M2 is environment (cytokine) dependent. And I don't remember whether M1 M2 is static, I think they are plastic.
I have not done this, but have seen the following references;
Chapter Genetic Models of Macrophage Depletion
Clodronate-liposome treatment is widely used for macrophage depletion, generally; http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.579.985&rep=rep1&type=pdf