How to download database from .sh type files?

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How to choose suitable solvent model for molecular dynamics?

I had ran molecular dynamic simulation on apo protein using TIP3P, TIP4P, TIP4PEW and SPC for 25 ns to establish the most suitable solvent model for specific protein. However, none of them gave...

04 May 2018 7,857 3 View

What is the number of cells and which culture plate that need to used for growth curve assay?

How much the cells that I need to use for developing growth curve of the cells? What is the size of cell culture plate that I need to use? Is there any standard guideline to follow? At the moment,...

06 July 2016 4,443 4 View

What the software can be use to predict the side effect of the compound?

I'm looking the free software as well as commercial software that can use to predict the side effects of the lead compound like liver toxicity and so on. Thanks.

03 April 2016 1,616 4 View

What is the different between conformation generated using LigPrep and ConfGen?

In library preparation, LigPrep will be used followed by ConfGen. Both of software will generate conformation. So, is it necessary to do ConfGen after LigPrep because both will generate the...

08 September 2015 1,888 0 View

Do I need to do ligand preparation and generate conformation before converting into ldb format?

I want to screen the compounds in Ligand Scout. So I need to convert the compound to lbd format as Ligand Scout only accept that format. Is it I need to do ligand preparation and generate...

07 August 2015 6,090 3 View

How can to know the compound that is synthesis is active for biological testing?

I already have synthesis compound. Is it I can directly use is for the study or I need to know the compound is active or not? So, how know whether the compound is active or not?

05 June 2015 7,958 2 View

What method can be used for developing multi-target inhibitor using in silico technique?

Reliable method that can be used.

02 March 2015 4,302 2 View

Is it necessary to measure the cytokines level as well as their protein expression at the same time?

May I know the different if we measure the cytokine level using ELISA and protein expression (Western blot and RT-PCR)? Some of the journal measure both.

01 February 2015 4,049 3 View

What is the best animal model for rheumatoid arthritis?

What the different between all the model? Preferably rat/mouse.

09 October 2014 3,377 9 View

Strugglling with m6A dot blot any suugesstion ?

I have been doing the m6A dot blot for a while with no improvement, I am extracting the RNA, and I can see the dots although the three biological replicas give a different reading on the memberan...

10 August 2024 8,539 5 View

How can I use the cif data obtained from rietveld refinement extracted via gsas2, for microstructural analysis using ETEX software?

09 August 2024 7,718 0 View

How to convert a privately loaded document into a public document?

I attempted to make a privately uploaded text public but a window appeared that said an error occurred. There was no explanation provided as to why there was an error or what might be done to...

05 August 2024 8,025 7 View

The aqueous fraction of the hydroethanolic extract is showing the presence of palmitic acid. What is the mechanism responsible ?

Palmitic acid presence in aqueous fraction

05 August 2024 8,624 4 View

Which solvent is better to dissolve with secondary metabolites extracted from fungi?

I work on MCF7 cell cell for anticaner purpose and I wa to do drug preperation the drug ( secondary metabolites extracted from Aspergillus) My question which solvent is better with these secodary...

03 August 2024 4,725 2 View

For systematic review data extraction, should I use ITT or PP analysis, and count all randomized participants or only those who completed the study?

I am conducting a systematic review and meta analysis; as I am extracting data I realized there is a consort diagram that shows the number of patients from randomization till end of the study. So...

01 August 2024 9,993 3 View

For the moringa oleifera extract using ethanol as the solvent,what is the alternative method to concentrate the extract other than rotary evaporation?

99% pure ethanol was used for maceration also alternate methods along with the temperature and time to concentrate the extract can be specified

31 July 2024 5,113 4 View

What are the factors that causes the sample to have higher efficacy at lower concentration?

We conducted an antibacterial study of a plant extract. Varying concentrations of crude extract were subjected to microbroth dilution assay. The result showed that only the lowest concentration of...

31 July 2024 8,666 3 View

What Are the Best Alternatives to the MTT Assay for Assessing Cell Toxicity of Colored Herbal Extracts?

I am currently investigating the cytotoxicity of a series of herbal extracts, and like many studies, I have been using the MTT assay to evaluate cell viability. However, I am encountering a...

31 July 2024 193 4 View

Hi there, someone has the SeinFit software for windows because I cannot download it?

DOS version.

29 July 2024 6,064 1 View