What the different between all the model? Preferably rat/mouse.
I was quite happy with adjuvan arthritis, easy and cheap animal model.
"Alterations in the Vascular Reactivity of Aorta in the Early and Late Phase
of Adjuvant-Induced Arthritis in Rat.
FCA sells in Sigma.
Collagen induced arthritis (CIA) rat model of RA is widely used and it shows the clear and most identical phenotype of all the RAT models available for RA. AIA is good in terms of severity represented in the RAT.
CIA is an IL-1 driven disease and we know that targetting IL-1 is not the best therapy
Collagen induced arthritis or Adjuvant induced arthritis Model are more relevant compared to other models.....Just decide the model depend upon your study...what you going to do .....what part of mechanism you want to interfere...? Consider the kinetics of the drug if your want to do some efficacy studies .....preference is also depends on your study mechanism....
Actually I am focusing PDE as a drug targets in rheumatoid arthritis.
It is unlikely that any of the popular animal models of arthritis bear any relation to RA in terms of immunopathology and since they are all inhumane I would avoid them. If you are wanting to study an anti-inflammatory effect (not sure what you mean by PDE) then there are much simpler systems like air pouches or paw oedema or even cell culture systems if you want to study specific pathways.
We have been working with the air pouch model of inflammation and I am very happy with it. While it is not technically an RA model as it does not involve bone or cartilage, the air pouch membrane has a similar composition to the synovium (FLS and macrophage like cells), and all treatments that are effective for RA (MTX, anti-TNF, steroids) also are effective in the air pouch model.
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