In library preparation, LigPrep will be used followed by ConfGen. Both of software will generate conformation. So, is it necessary to do ConfGen after LigPrep because both will generate the conformation of compounds. Please advice.
I had ran molecular dynamic simulation on apo protein using TIP3P, TIP4P, TIP4PEW and SPC for 25 ns to establish the most suitable solvent model for specific protein. However, none of them gave...
04 May 2018 7,857 3 View
How much the cells that I need to use for developing growth curve of the cells? What is the size of cell culture plate that I need to use? Is there any standard guideline to follow? At the moment,...
06 July 2016 4,443 4 View
I'm looking the free software as well as commercial software that can use to predict the side effects of the lead compound like liver toxicity and so on. Thanks.
03 April 2016 1,616 4 View
I want to screen the compounds in Ligand Scout. So I need to convert the compound to lbd format as Ligand Scout only accept that format. Is it I need to do ligand preparation and generate...
07 August 2015 6,090 3 View
I already have synthesis compound. Is it I can directly use is for the study or I need to know the compound is active or not? So, how know whether the compound is active or not?
05 June 2015 7,958 2 View
Reliable method that can be used.
02 March 2015 4,302 2 View
May I know the different if we measure the cytokine level using ELISA and protein expression (Western blot and RT-PCR)? Some of the journal measure both.
01 February 2015 4,049 3 View
I have download the chemical database in .sh type files. How can extract it to .sdf files? I'm using Windows.
11 December 2014 9,942 2 View
What the different between all the model? Preferably rat/mouse.
09 October 2014 3,377 9 View
Hello experts, Does anyone know any free software about retention index prediction ?
08 August 2024 7,403 2 View
I did PR spin coating on trench structure. I used AZ P4620 PR and the thickness or PR is around 11um. The substrate is Si. And my trench structure depth is 141um(negative way). Even though I...
08 August 2024 2,298 0 View
Molecular docking software/ websites?
02 August 2024 8,704 7 View
I want to perform a CRISPRa/i library screening for candidate regulatory factors that affect pathogenic Th17 differentiation in PBMC. But I am wondering how to define the size of gene library, so...
31 July 2024 2,150 0 View
When I run autogrid4 it says: autogrid4: ERROR: Unknown receptor type: "Cr" -- Add parameters for it to the parameter library first! Look forward to your reply.Thank you so much!
29 July 2024 488 0 View
I created a file with my outgroup and ingroup species using Beauti, ran it in BEAST, viewed it in Tracer, and then used TreeAnnotator to create a file that I imported into RASP. Could someone...
28 July 2024 2,979 1 View
I am reaching out to seek your valuable advice and recommendations regarding the best software tools to use for this research. Specifically, I am looking for software with a user-friendly...
22 July 2024 3,794 1 View
Hey all, I need help testing for multivariate outliers using STATA for my master thesis. The literature recommends the Minimum Covariance Determinant (MCD) (Verardi & Dehon, 2010). I found the...
22 July 2024 8,821 2 View
Dear Researchers, My question is associated with the "MDCI" method in Orca. Please let me clarify my question using a simple example: Suppose we are going to perform CBS extrapolation using "!...
21 July 2024 1,632 0 View
> library(meta) Error: package or namespace load failed for ‘meta’ in loadNamespace(i, c(lib.loc, .libPaths()), versionCheck = vI[[i]]): there is no package called ‘numDeriv’
18 July 2024 3,536 0 View