I have a platinum-based antitumor drug, it can work well in many types of cancer cell lines, now I'm going to make sure the mechanism and want to know the cellular distribution of this drug, are they accumulated in the nucleus or in the cytoplasm. Can anyone give me some suggestion, and is there any way to image the distribution of platinum in cells, Thank you.
Do not you use conjugation of dyes for in vivo imaging? I am not an expert in the field. Just I suggest to think about it.
X ray?
https://en.wikipedia.org/wiki/X-ray_crystallography
I would like to thank all of you for your replies.
To Alemu Tekewe, it's a good idea that I can check is it possible to do the fluorescent conjugation.
To Joachim Pimiskern, thanks for your articles sharing, I got some ideas that I can try in the future.
To Ana María Sánchez Peralta, I never thought it before until I googled the keywords in platinum drug and X-ray, an interesting paper is related to my question.
https://www.nature.com/articles/srep38507
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