How to classify Tumor Mutation Burden into TMB high, medium and low groups ?

02 September 2020 1 5K Report

Tumor mutational burden (TMB) is a measure of the number of gene mutations inside the cancer cells. TMB of a tumor sample is calculated by the number of non-synonymous somatic mutations per mega-base in coding regions. The value obtained for TMB always ranges from 0 to 1 which never reaches 1. What is the minimal cut-off that can be assigned to classify TMB as High, Medium and Low?

Walid Hassene Hamri

Hi,

You will find in the links below a specified cut-off for stratifying the tumor mutation burden.

You can go through these papers:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353746/

https://www.frontiersin.org/articles/10.3389/fonc.2019.01161/full

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510391/

Hope this may help you.

Badges
Science topic

More Snijesh V.P.'s questions See All

How to extract list of proteins delectable by immune histochemistry?

Is there any database or tool where I can retrieve list of proteins detectable by immune histochemistry (IHC)?

02 August 2020 7,539 2 View

How to remove a non-ionic surfactant (eg-tween20) from the reaction mixture?

I attempted to prepare CuS nanomaterials using microemulsion method. I used tween20 as the surfactant. But found it is very difficult to remove the surfactant from microemulsion. How can we remove...

23 June 2020 5,382 17 View

How to measure Lowest Detection Limit of a sensor material in Electrochemical sensing?

I know Differential Pulse Voltametry is using to measure LOD value. But I do not know how to measure the Lowest Detection Limit of a sensor in Electrochemical sensing. Please reply. Thanks.

09 March 2020 3,371 3 View

What is the longest deletion or insertion that can be detected in next generation sequencing data analysis?

what is the longest deletion or insertion that can be detected in next generation sequencing data analysis

26 February 2020 2,844 3 View

How to perform normalization and calculate when there are multiple groups ?

I have 4 sample [control, pre-treatment, post-treatment, metastais] with 4 replicates which make total 4x4 = 16 samples I want to perform comparison of control with all other groups. For the said...

12 February 2020 6,258 2 View

How does batch correction of gene expression data affect accuracy?

I have two batches of samples which were collected during two time period. If I perform batch correction to remove batch effect will it affect the downstream analysis of gene expression studies?

19 December 2019 764 3 View

How to get an endorsement in arXiv (cs.CG)?

I have been struggling to get endorsement for putting preprint in arXiv. What is the best method to get endorsement in arXiv for computational geometry in computer science (cs.CG)?

29 October 2019 9,281 1 View

Can any one suggest me the way of getting Agricultural SAR images? or any database available?

Agri-SAR image database?

24 July 2018 4,776 3 View

What are the best tools for Data Mining Techniques for Harvesting Data from the Internet?

I want to extract the data from the internet with specific medical terms. Which are the available tools with best accuracy or output?

06 February 2018 6,620 5 View

Organs and part of organ classification?

Hi, I think there are about 80 organs in the human body. When I searched for list of all organs different sites are showing different list. Are there any books or publication that clearly mentions...

10 November 2017 8,732 4 View

Why does blocking with my immunogenic peptide cause nuclear fluorescence in ICC?

Hi all, I am validating a polyclonal antibody raised against human ANT4, through WB and ICC. In most of my controls, the antibody shows very little off-target binding, but when I pre-incubate the...

03 March 2021 5,999 3 View

Is there a powerful system for the security of the systems distributed on IoT systems?

02 March 2021 3,858 10 View

Does Napabucasin soluble in dichloromethane and in ethanol?

I need to prepare a solution of Napabucasin (inhibitor of cancer cell stemness) in dichloromethane. The drug is expensive, so maybe somebody already tried to do it. If it is soluble, what is the...

02 March 2021 9,945 3 View

Help request in CST microwave?

im working now on TPV solar cells and metamaterials and i realy need our help in CST microwave i have a tpv cell simulation and i want to extract particullarly the absorbtion of only the active...

02 March 2021 2,246 2 View

How Relativistic effects is one reason for lanthanide contraction?

The Lanthanide contraction which is the decrease in ionic radii of the elements in the lanthanide series from atomic number 57, lanthanum, to 71, lutetium, is due to poor shielding of the 4f...

01 March 2021 2,272 4 View

Could you please recommend some good journal that accept very long revie papers (approximately 6000+ words) in neurosurgery, cancer biology ?

01 March 2021 8,087 3 View

Which cell line should we use to perform biological dosimetry experiments?

We are preparing some experiments based on irradiating cells under different conditions in order to evaluate the effects in terms of DNA damage, genetic expression, etc. As our project is...

01 March 2021 3,355 3 View

How to avoid ulcers in s.c. injected tumors ?

Recently, we have injected s.c. B16F10 tumor cells in BL/6 mice. At around 12-15th day some animals showed ulcerations in tumors , with a big hole in the middle (it looks like a volcano). We have...

01 March 2021 9,938 3 View

Is CD44 degraded in lysosome together with hyaluronan after CD44 mediated endocytosis of hyaluronic acid?

Also when RHAMM binds hyaluronic acid, they get internalized, will RHAMM also be degraded? Or both CD44 and RHAMM will be transferred back to the cell membrane? Asking for breast cancer cell line...

01 March 2021 8,169 2 View

Dapi fluorescence protocol for colon cell lines ?

28 February 2021 2,534 2 View