Can we patent a drug moiety arising out of natural product research?

Hi All We are involved in natural product drug research involving activity guided fractionation, structural characterisation and insilico science. I request your guidance in the patenting norms...

09 October 2018 9,839 0 View

How to interpret the nmr and mass spectral data?

Dear All Please guide me how to interpret the structure of phytoconstituent from crude extract of natural product sequentially Is there any online available tools to interpret the data

11 December 2016 3,727 3 View

How to optimize plant fraction for anti inflammatory potential?

Hi all I wish to optimise my antiinflammatory fraction of plant to successful lead against inflammation, After separation and optimisation insilico how to progress with and invivo evaluation of...

08 September 2016 499 3 View

Synthesis /Semisynthesis of natural product ? Design of synthesis procedure for natural product

Hi All I want to test my isolated phytoconstituent for some biological activity( i.e antidiabetic or anticancer).How to screen individual phytoconstituent or the synthetic analog is potent?. How...

03 April 2016 5,933 4 View

Can we study the anticancer activity of two phytoconstituents (in combination) to treat inflammation/cancer in cell lines/animal models ?

Hi All I am planning to study the molecular mechanism that link inflammation and cancer. I request you to advice me that whether two phytoconstituents(which share same biological property) can be...

02 March 2016 9,949 4 View

How to study the 3D QSAR modelling of phytoconstituents in Accelyrs Discovery studio?

Dear All We are doing pharmacophore modelling of our phytoconstituents from Brassica sps in Accelyrs Discovery studio. Kindly guide me in doing 3D QSAR modelling in Accelyrs discovery studio.

02 March 2016 5,238 0 View

How to quantify vitamins in plant extracts

01 February 2016 5,742 4 View

Phytosomes to target and treat cancer tissues

Sir Can we use phytosomes to target, treat and sensitise cancer tissues?

01 February 2016 9,389 3 View

Quantification and identification of vitamin in plant extract How to quantify vitamins such as A D E K in plant extracts?

Your toughest technical questions will likely get answered within 48 hours on ResearchGate, the professional network for scientists.

07 August 2015 1,016 0 View

Can we patent a drug moiety arising out of natural product research?

Hi All We are involved in Natural Product Research.Can we patent a lead drug moiety arising out of Natural Product Research. Regds J Renuka

01 January 1970 9,786 15 View

Why does blocking with my immunogenic peptide cause nuclear fluorescence in ICC?

Hi all, I am validating a polyclonal antibody raised against human ANT4, through WB and ICC. In most of my controls, the antibody shows very little off-target binding, but when I pre-incubate the...

03 March 2021 5,999 3 View

What's the best way to measure growth rates in House sparrow chicks from day 2 to day 10?

What's the best way to measure growth rates in House sparrow chicks from day 2 to day 10? Since, the growth curve from day 2 to 10 won't be like the "Logistic curve" it might not follow logistic...

03 March 2021 1,401 3 View

After a reference from Int J Body Compos Res, can any body help?

Hi, I am after the reference below, my library says it cannot obtain a copy either locally or internationally, any help appreciated! Chris Wang ZM, Heshka S, Wielopolski L, Pi-Sunyer FX, Pierson...

03 March 2021 6,193 1 View

What techniques can I use to determine the miscibility of polymer blends?

The term miscibility refers to the single-phase state in thermodynamics. I do not mean the compatibility of different components. To determine the miscibility I know several techniques such as...

03 March 2021 4,107 4 View

How do I increase the yield of my PCR product?

Hello, We would like to increase the yield of our PCR product. We are running a series of PCR reactions that is targeting ~1.1kb sequence. We begin each reaction with ~400pg of template DNA...

02 March 2021 4,029 3 View

How to repeat an operation on an atom selection for multiple times in PyMol?

Hi, I am trying to construct a multi-layer fibril structure from a single layer in PyMol by translating the layer along the fibril axis. For now, I am able to use the Translate command in PyMol...

02 March 2021 4,569 4 View

Does Napabucasin soluble in dichloromethane and in ethanol?

I need to prepare a solution of Napabucasin (inhibitor of cancer cell stemness) in dichloromethane. The drug is expensive, so maybe somebody already tried to do it. If it is soluble, what is the...

02 March 2021 9,945 3 View

Help request in CST microwave?

im working now on TPV solar cells and metamaterials and i realy need our help in CST microwave i have a tpv cell simulation and i want to extract particullarly the absorbtion of only the active...

02 March 2021 2,246 2 View

Shall I skip the measurement model in SmartPLS?

Hello everyone, I had run a mediation model in SmartPLS using questionnaires that were already validated among my statistical population. A professor who edited my paper -though she is not...

01 March 2021 3,052 3 View

What is involved in morphological changes of SEM images of a substance?

In the sem analysis of CaCO3 nanaoparticles, the morphology images showed spherical shaped particles but the proposed morphology for these type of nanoparticles is trigonal. I prepared the...

01 March 2021 1,960 4 View