We know that wen rat is given with streptozotocin beta cells are damaged , further research on pancreas shows it holds good?
STZ is beta cell toxicant and it damages beta cell its well known fact..its a one of the golden standard method to induce Type-I diabetes in animal model. wat type of further research u planning to do on endocrine pancreas...like any therapeautic mechanistic approach...further questions are welcome because i m not clear with your query. If any i can i will help u Mr.Arun
All the very best
STZ is a drug that promotes apoptosis of beta pancreatic cells and can determine the status of type I diabetes. However, different doses of STZ can be adopted for a protocol used to induce diabetes (eg. 60mg/kg body weight ). Thus, depending on dose, the lineage of the animal, the age of the animal, etc., the result can be variable. Further, usually a number of residual pancreatic cells remain functional, which were not totally affected by STZ and which are still capable of secreting insulin. How these residual cells are affected? What are the mechanisms involved in the survival and "resistance" of these cells to treatment with STZ? Research are needed to clarify these cellular responses in the pancreas of rodents receiving STZ to induce diabetes type I.
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