Why are wistar rats specifically used in diabetic models?

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Why i do get black particles in cell culture and i also have dead cells adhered to my grown live cells and its like just waves?

I grow LC-540 cells and my cells are clear when fully grown image 1, but when I trypsinize the same plate I see black particles image 2. When I subculture them on a new plate I don't see those...

02 March 2020 6,635 1 View

Help me Identify the problem with these cells (LC540 Leydig cells)?

I grow LC-540 Leydig cells, the problem with me is as shown in the picture a. The ones rounded in yellow circles are black particles attached to the plate loosely it does not show any movement,...

03 April 2019 5,301 5 View

Oocyte swelling assay detail protocol. Aquaporin inhibition studies. Any suggestions for other studies?

I am completely unaware of swelling assay as i am from a different back ground. I have a compound which i hypothesize that it will inhibit aquaporin. I am not sure that it would make any gene or...

02 March 2018 2,938 0 View

Does high or low glucose has its effect on total AMPK (not phosphorylated AMPK) in cells during treatment?

I have been using endothelial cells with various conc of glucose from 1.5mM to 30mM. I have changes in total AMPK protein expression using AMPK alpha1/2 santa cruz. I just went through some...

04 May 2016 8,475 2 View

Best compound or drug to inhibit aquaporin expression other than mercury?

I have been working on aquaporins and literaturre says merrcury inhibits AQPs. Few published articles say Thrombin, TPA, bumetadine, Propofol pholoretin etc.. CAn someone suggest me the best among...

02 March 2016 7,441 8 View

This picture is LC540 leydig cells... The red arrows indicate black dots and the yellow arrows indicates bubbles. What are these stuff?

I'm new to cell culture and i have started with Lc540 leydig cells i started growing the cells and i notice these black dots as shown in the picture in red arrows and it doesn't affect my culture...

08 September 2015 4,093 8 View

Any one working in the field of reproduction with sertoli cells?

Sertoli cell line

10 November 2014 6,620 1 View

How do you mimic diabetes conditions in-vitro to study the effect on reproductive organs (e.g. in testes)?

Diabetes has many complications, one of which is on reproduction (infertility). How can I mimic diabetes condition in a testes cell line? I have seen papers in which a pancreas (beta cell line)...

02 March 2014 7,796 7 View

Why are my rats dying after 48 hrs when I induce them with STZ 65?

Rats 0f 250-300mg each mg/kg.

01 February 2014 759 14 View

How reliable is an analysis of pancreas on stretozotocin induced diabetic rats?

We know that wen rat is given with streptozotocin beta cells are damaged , further research on pancreas shows it holds good?

01 February 2014 7,394 2 View

How to mimic diabetic conditions in cell culture?

Is there a protocol to establish diabetic conditions in pre-osteoblasts cell culture?

18 June 2024 9,306 2 View

How does the presence of diabetes affect the prognosis of myocardial infarction?

Comprehensive Overview of Myocardial Infarction: Etiology, E... How does the presence of diabetes affect the prognosis of myocardial infarction?

15 June 2024 1,038 3 View

Is the prevalence of shoulder frozen is higher in Diabetic patients?

the prevalence of shoulder frozen is much higher in diabetic patients than non diabetic, and what will be the cause? There is many reports but still not will understood.

10 June 2024 3,270 3 View

Peer support in adolescents with type 1 diabetes?

Type 1 diabetes, the effect of peer support in self care efficacy, emotional well being

27 May 2024 4,325 0 View

To what extent can the manipulation of genes be considered a successful approach for treating type 1 diabetes?

and what are some possible implications for the patient

19 May 2024 9,792 3 View

How does rosiglitazone improve insulin sensitivity in patients with type 2 diabetes mellitus?

Efficacy and Safety of Rosiglitazone in the Management of Ty... How does rosiglitazone improve insulin sensitivity in patients with type 2 diabetes mellitus?

17 May 2024 9,061 0 View

How does rosiglitazone improve insulin sensitivity in patients with type 2 diabetes mellitus?

Efficacy and Safety of Rosiglitazone in the Management of Ty... How does rosiglitazone improve insulin sensitivity in patients with type 2 diabetes mellitus?

17 May 2024 3,759 1 View

How does rosiglitazone improve insulin sensitivity in patients with type 2 diabetes mellitus?

Efficacy and Safety of Rosiglitazone in the Management of Ty... How does rosiglitazone improve insulin sensitivity in patients with type 2 diabetes mellitus?

17 May 2024 7,387 0 View

How might the future of metformin therapy evolve based on current research trends and advancements in diabetes care?

Comprehensive Review of Metformin: Indications, Contraindica... How might the future of metformin therapy evolve based on current research trends and advancements in diabetes care?

12 May 2024 7,198 2 View

What are some effective strategies for weight management in patients with type 2 diabetes mellitus, and how do they contribute to overall treatment?

Comprehensive Management of Type 2 Diabetes Mellitus: From P... What are some effective strategies for weight management in patients with type 2 diabetes mellitus, and how do they contribute to...

12 May 2024 7,271 2 View

Salih Sanlioglu

In our experience, Wistar rats are suitable for induction of Type 1 diabetes by way of STZ injection. SD rats, however, are better for induction of obesity induced Type 2 diabetes, though the gold standard is C57BL6J.

Md. Shahidul Islam

Wistar and SD both rat strains are being used. These rats are lower in cost, reasonable size for sample blood and organ sample collection, easy to maintain because of their tranquil behavior and widely available in the world. These are some of the reasons. I am also agreed that SD rats is better for T2D model than T1D.