They have load of iron which must induce lipid peroxydation via ferroptosis !!!
What prevent them to burst quickly?
The classic theme about the fact they don't have a nucleus is about physical constraint. What if they didn't have nuclei to prevent some nasty effects from ferroptosis?
Hi Girard,
Ferroptosis is a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides. Erythrocytes are highly specialized cells that utilize a large amount of iron to bind and deliver oxygen to all tissues. Being constantly exposed to oxygen, erythroid cells need to continuously fight against oxidative stress by expressing a variety of antioxidant enzymes, including GPX4. Lipophilic antioxidants and iron chelators can prevent ferroptotic cell death of RBCs
Bipolar lipid layer and typical protein skeletal prevent the nasty effects from ferroptosis
Hopefully meaningful reply to your question .
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