I read in a journal that RNAi may occurred naturally as antiviral mechanisms. In biotechnology, it's also used for gene silencing. Recently, I read that in general, RNAi does contribute in gene up and down regulations. However, as it silence the gene by binding to the mRNA, how could the RNA allow some genes to be up regulated? Please enlighten me because this case is new to me.
Hi,
I liked this article, although it's probably similar to the one from Reza Shokri Gharelo:
"Small RNA and transcriptional upregulation"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154074/
Hello Adhityo
The effect of RNAi function supress its target gene and decrease the protein translation. It is direct effect. Whether you study others genes or protein expression respect the target gene, you can observe an up- or- donwregulation.
Regards
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