How inhibiting the activity of a single oncogene and its associated pathway in vitro and or in vivo kills the tumor cell ?

09 September 2012 0 9K Report

It is well known that Single mutant Proto Oncogene is not sufficient to initiate tumor /bring Biochemical and morphological charecterisitc associted with tumor such as foci formation,invasion etc , both in Vivo and In Vitro. Then how come inhibiting the activity of single mutant proto oncogene (or) its pathway e.g PI3K which has commitment in cell progression ,survival ,motility,angiogenesis etc ) in Cancer cell kills the cancer cell -at least few Invitro and Invivo ,,

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