Indapamide is used to control hypertension in patients who have CHF with overt signs of oedema. A serious side-effect of this drugs is hypokalaemia, as with other loop and thiazide diuretics. There have been several reports of indapamide-induced hypertensive crisis which further limits its use. What's the pathophysiological mechanism behind this? How can an antihypertensive agent induce hypertensive crisis?
Between January 2004 and October 2012, 13 individuals taking indapamide reported hypertensive crisis to the FDA. (source FactMed)
The following Indapamide Hypertensive Crisis side effect reports were submitted by healthcare professionals and consumers.
This information will help you understand how side effects, such as Hypertensive Crisis, can occur, and what you can do about them.
A side effect could appear soon after you start Indapamide or it might take time to develop.
This Hypertensive Crisis side effect was reported by a consumer or non-health professional from VENEZUELA. A 79-year-old female patient (weight:NA) experienced the following symptoms/conditions: hypertension. The patient was prescribed Indapamide (dosage: NA), which was started on Oct 01, 2010. Concurrently used drugs:
Caduet ([amlodipine Besilate 5 Mg/ Atorvastatin Calcium 40 Mg], 1x/day)
When starting to take Indapamide the consumer reported the following symptoms:
Renal Impairment
Blood Creatinine Increased
Blood Urea Increased
Hypertensive Crisis
These side effects may potentially be related to Indapamide.
For more plz read at folowing link
http://patientsville.com/indapamide/hypertensive-crisis.htm
Indapamide is a diuretic drug with similar functions and applications with thiazide diuretics.See ( hydrochlorothiazide), although not with thiazide ring system. It is used in blood pressure and edema associated with heart failure used.In some countries, Indapamide hemihydrate as described.It easily and completely absorbed through the digestive tract.
Qrmzkhvn cells connected with the power to extensively metabolized and approximately 60 to 70% of the dose is excreted through the urine.
The impact of these drugs on emotional triggers the sensory pathways of the hypothalamus activates the autonomic-endocrine system or the impact on physiological parameters such as heart and respiratory rate and blood pressure to answer Tghyr
The case referenced by Dr A R Ali Aldallal describes prerenal acute kidney injury, but not a hypertensive crisis. Increase in blood pressure is mediated, not a direct side effect of indapamide. Ischemia of juxtaglomerular cells
(initially relative hypovolemia and lowering blood pressure) activated the Renin-Angiotensin-Aldosteron-System. This further led to secondary high blood pressure.
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