Suppose I need to target mitochondria to address malignancy-related problems. Are there peptide-based ligands similar to Nuclear Localization Signals (NLS) for nuclear targeting that can be used for mitochondrial targeting? Can Matrix Targeting Sequences (MTS) be used for this purpose?
Hello Bhaskar,
That can be done. To facilitate cellular uptake of your MTS-based nanodrug delivery system, the MTS will need to be conjugated or fused (if you are generating the MTS via plasmids) with another moeity.
Check out these manuscripts that feature various MTSs and ways to integrate them in nanocarriers.
Article Development of Peptide-Based Nanoparticles for Mitochondrial...
Article Dual Peptide Conjugation Strategy for Improved Cellular Upta...
Article Mitochondria-Targeted Nanocarriers Promote Highly Efficient ...
Article Gene delivery to mitochondria by targeting modified adenoass...
Article Synthetic Mitochondria-Targeting Peptides Incorporating α-Am...
https://www.nature.com/articles/s12276-018-0124-z
Hope this helps!
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