Dried protein pellets are alway hard to resuspend, but resuspensing directly in SDS buffer is not a good idea. This is what worked to be: vortex the 'dry' pellet, or add just 1-5 µl of water and vortex vigorously untill you have a slurrey. Now you can add the SDS buffer, pipette up and own and vortex further. Always dissolve a (re)suspension never a pellet.

Hi Bharat, use a sonicating waterbath with RIPA buffers. It does wonders with insoluble proteins in glass tubes.

BTW, you are at VCU, my alma mater. My PhD advisor was the late Herbert  Evans, who now has an award for student attchivement.

Please send me a personal message of how things are going there. 

I want to know what happened to the biochemistry/medicine faculty after I graduated in 1991.

I mainly used TCA precipitation but experienced similar troubles with solubilization of the pellets. As mentioned above, sonication does a really good job. Sometimes I was also using extra urea in the solubilization buffer (6M), but I can imagine it might be not compatible with all the experiments.

And before you redissolve the protein, make sure there is no aceton left, e.g. by lyophilisation.

I agree with the previous commenters that sonication works well. I also find that over-dring the pellet makes it harder to resuspend. Suction off the supernatant, then place the tubes in a 37°C block for a few minutes or just leave them at room temperature. Any residue liquid should evaporate, but the pellet should not lift off the tube. If you can, do just a TCA precipitation then make sure your resuspension buffer contains a high enough buffer concentration to neutralise the TCA. I find these pellets resuspend much better than acetone ones. Good luck!