Are there any specific markers for recognizing the stages of Alzheimer (mild, severe etc) in rodents. I wish to induce the same using streptozotocin, and transplant stem cells both at an early and late stage of alzheimer progression? But I am not aware how to know about the stages. Please kindly suggest.
Many thanks,
Syed
This is not at all my field, but papers in high impact journals tend to feature the following:
Performance on behavioral and cognitive tasks relating to expected loss of function in different domains.like sensory, motor, emotional, executive
Histology or molecular biology to quantify neurodegeneration/neuroinflammation and/or abeta or tau accumulation.
Since you're implanting stem cells you'll also want a way to check that they stick around.
I doubt if we can speak about " Alzheimerws Disease " in rodents .It is probably a lab model used for research purposes and should be named accordingly.
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