Dear Mahmoud, your questions cover overall course of Oncoimmunology. I think, ResearchGate is more suitable for discussion of much more specific problems. Hope, it will be easy for you to find answers in text books and current scientific literature. There is a lot of publications devoted to these greatest themes. Evidently, they do not fit to simple discussion on social network forum. I would recommend you my review https://www.researchgate.net/publication/6126953_Intrathymic_selection_new_insight_into_tumor_immunology

Your first question and counter-question from me: In frames of current paradigm cancer cells are result of subsequent mutations and contain mutant proteins, which are antigenic for immune system. In reality there are several hudreds of proteins participating in oncogenic transformation, and mutations at 6-8 from them in the progenies of one cell can induce malignant phenotype. Why do you need "to generate" any single "antigen on the cancer cell surface"? Will be this helpful, appropriate and related for the treatment of patient with individual set of mutations in cancer cells and individual profile of MHC molecules, which really "generate an antigen" on the cancer cell surface? If you say "no", your subsequent questions lose meaning.

Article Intrathymic Selection: New Insight into Tumor Immunology

Dear Prof. Dr. Dmitry,

Thanks for your detailed comment.

first of all: there is no course here in Egypt nominated as oncoimmunology, that's why I am collected my data online.

it will be better to identify more than one surface cancer antigen, the point is I have an idea for cancerous antigen presentation in vitro to be extrapolated in vivo.

the new issues in my idea are:

1- presenting the antigen to dendritic cells while the cancer cells are attenuated (survival cells and inactivated in the same time).

2- presenting surface antigens only.

3- usage of B-cells in antibody production to evade metastasis as well as immunotherapy.

I do not have enough lab feasibilities to do this research here in Egypt. Can you help me find a position in lab interested in this kind of work.

I can send you the proposal outline to revise it.

Dear Mahmoud, please, carefully read my review. It may be, you will see new ways to enhance your research project. I wish you all the best and to be in safety in this very hard period for Egypt. Some people in Russia say: "When the house in the fire, the clock is ticking." I think, this will be right position.

I am reading it carefully now.

Some people in Russia say: "When the house in the fire, the clock is ticking." I think, this will be right position. what does it mean ?

Social cataclisms should not disturb scientists. The best places for them are laboratory and library. Later, the life will be normalized in Egypt, but your departure now will mean, that there will be no Oncoimmunology in Cairo. Never! Twenty years ago, similar events took place in Russia. So, I well know, what I say. Formerly, the same was suffered by Louis Pasteur in France.

Dear Prof. Dr. Dmitry, At least I am seeking a chance to learn the best from the best then I can come back to my home country, without learning abroad how could I be advanced and be the best ??

Dear Mahmoud, in science, as in art, PERSONAL ORIGINAL IMPACT has the greatest value. The difference implies your compliance with strong standards of scientific research. Get the knowledge as much as possible! Be unbiased! Call in question everything! Worry about correct controls! Do not copy other's studies! Get your OWN ORIGINAL experience! Make your OWN ORIGINAL scientifc field, be anxious to integrate your OWN scientific experience and ORIGINAL results into world science! Find followers! Then, you will be the best.

wow, this is the wisdom.

Thanks Dr. Dmitry for your advice.

Thanks! Good luck!