How can I compare two (or more) networks?

Suppose you have built a network based on gene expression or protein interaction. How can I compare the current network with that from KEGG? Is there any statistics or software? Best regards,

31 December 2014 115 3 View

How can I methylate or demethylate certain loci in human cell lines?

31 December 2014 2,586 3 View

Is there any recommended pipeline or procedure for Illumina Methylation 450K microarray analysis?

Is there any recommended pipeline or procedure for Illumina methylation 450K array analysis. and What we can do as a analyst when we obtain some methylation 450K array for some paired case and...

31 December 2014 4,793 9 View

Can anyone help to make a pathway analysis with Ingenuity Pathway Analysis?

31 December 2014 5,605 3 View

Do you know of any R packages for analysis of case-control studies in genetic epidemiology?

As we know, case-control based genetic epidemiological studies has played important role in susceptibility factor identification. Now, would you mind suggesting some helpful R packages to do SNP...

31 December 2014 701 3 View

How can I do sample size estimation for GWAS study?

Usually, when we conducted candidate gene based association study, we need to estimate the sample size and the power. Is it necessary to do it when we conduct GWAS study? If yes, is there any...

31 December 2014 7,577 2 View

Is there any article on Relationship between DNA Methylation and Human Evolution?

DNA methylation was involved in the evolution of duplicate genes, gene expression, miRNA network stability. Question, Is there any great article to discuss The Relationship between DNA Methylation...

31 December 2014 3,815 1 View

Powerful pipeline for miRNA-seq analysis?

Which pipeline is a suitable one for miRNA-seq analysis? CAP-miRSeq, miRNAkey or others?

31 December 2014 114 4 View

How can I get the KEGG Pathway Network in mathematical form?

We can get the elements (genes) of each pathway of KEGG from KEGG website of UCSC database. However, how can we get the network relationship in the form of network for KEGG pathway as the...

31 December 2014 2,665 3 View

Can we perform Extension of Methylation of the 450K microarray?

As we know that Methylation 27K and 450K has been widely used in genome-wide DNA methylation detection. However, they are still very small compared with whole genome CpG sites. Is there any larger...

31 December 2014 6,243 0 View

How to compare two groups with only two measurements?

Hiiiii everyone! I have an enquiry on statistical analysis. I was looking for many forum and it's still cannot solve my problem. I want to compare means of two groups of data but only with two...

03 March 2021 8,796 3 View

Enhanced Yellow Fluorescent Protein (Aequorea victoria) DNA sequence?

I am on the lookout for the Enhanced Yellow Fluorescent Protein (Aequorea victoria) DNA sequence. Does anyone know where I can find it? Thank you in advance

03 March 2021 3,568 1 View

What kind of fluid could I use for a pitfall trap that also does not invalidate molecular testing?

Hi, I want to start testing pitfall trap to obtain ants samples, but I need to conduct molecular analysis on those insects. So, what kind of fluid can I use? Ethanol expires too early and I need...

03 March 2021 5,978 5 View

What's the best way to measure growth rates in House sparrow chicks from day 2 to day 10?

What's the best way to measure growth rates in House sparrow chicks from day 2 to day 10? Since, the growth curve from day 2 to 10 won't be like the "Logistic curve" it might not follow logistic...

03 March 2021 1,401 3 View

Do we need to write protocol for a second study of a systematic review that has been registered and published?

I have conducted and published a systematic review and meta-analysis research with the topic related to public health and health pomotion (protocol was registed in PROSPERO). Now we want to...

03 March 2021 8,920 3 View

How to increase a model accuracy ?

dear community, my model is based feature extraction from non stationary signals using discrete Wavelet Transform and then using statistical features then machine learning classifiers in order to...

03 March 2021 6,994 5 View

Do I need to do linear regression before running mediation analysis using PROCESS MACRO by Hayes ?

I just wanted to check if I need to run a linear regression separately if I am using PROCESS MACRO to run mediation analysis. Thank you.

02 March 2021 4,359 3 View

Sample dilution for quantitative analysis using ELISA?

If the detection range is in ng/ml but the reference range is in ug/ml for a molecule or protein in serum or plasma .how to dilute and what is the initial volume to be taken for quantitative analysis

02 March 2021 7,670 3 View

Is There Any Feasible Method To Test Fluorescent Compounds Other Than Fluorescence Spectrometers ??

Is There Any Feasible Method To Test The Efficiency Of Fluorescent Compounds Other Than UV Spectrometers ? Suggestions Would Be Appreciated !

02 March 2021 5,785 3 View

How to repeat an operation on an atom selection for multiple times in PyMol?

Hi, I am trying to construct a multi-layer fibril structure from a single layer in PyMol by translating the layer along the fibril axis. For now, I am able to use the Translate command in PyMol...

02 March 2021 4,569 4 View