Usually, when we conducted candidate gene based association study, we need to estimate the sample size and the power. Is it necessary to do it when we conduct GWAS study? If yes, is there any recommended method, software or R package which can do it? I hope the method or software recommended can be implemented on Linux (Ubuntu).
Your reply or help would be greatly appreciated.
Best regards,
GWAS looks for differences on SNPs frequencies, and benefit from exploratory/descriptive designs - usually with no prior assumptiom of alele distribuition. An example: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719288/
Hi,
Your question: How can I do sample size estimation for GWAS study?
Kindly see the link related to Genome-Wide Association Studies (GWAS Study)
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1000477
http://www-stat.wharton.upenn.edu/~tcai/paper/SparseSNP.pdf
http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1002822
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