In our study, we found that a certain transcription factor positively regulates genes involved in pullulan biosynthesis. However, when this factor is deleted, genes related to melanin biosynthesis become upregulated, and melanin production increases, suggesting that in its presence, it acts as a repressor of melanin-related genes.
this raises a key question, what makes the transcription factor behave differently at the promoters of melanin-related genes compared to pullulan-related genes?
I would appreciate any insights regarding dual-function transcription factors in fungi or other eukaryotic systems.
Hi Khalef,
you missed something, your TF is probably not controlling only one gene, but surely it regulates many genes interacting with each other.
pathways with TF are complex and few changes (mutations, environment, epigenetic..) can have huge impact as a result.
look at this database: https://tfbsdb.systemsbiology.net
all the best
fred
Hi Fred,
Thanks a lot for your helpful comment and the link to the database. You're right, the TF I'm working on regulates many genes, but it seems to affect them differently.
Really appreciate.
Best, Khalef
life is life and pathways do not show easily how they work
if you look at egg pathways it's simple, but in fact these ones are dynamically interacting.
it's just a question of balance between partners, and sometimes partners are from the same family...which doesn't help in the comprehension.
best luck
fred
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