Hi do you think that NO-hemoglobin is good marker of LPS induced septic shock in mice?

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Angela Tesse

Hi Karel,

yes I think that hemoglobin could be linked to NO when there is a strong NO production due to inflammation of septic shock, that could be a very intersting subject of research!

Irina Lobysheva

Hi Karel, it is good question, actually, in this murine model NO is intensively produced due to iNOS expression, and erythrocyte HbNO is following increased NO production, but the effect of increased level of ROS would change the balance and HbNO levels back. The kinetic model was tested in rat blood (0-72 h. after endotoxin administration): FR Res Comms 1990 (11 :167-178).