Hi. According to many references N-methy-pyrrolidone (NMP) is used for the formulation of drugs intended for the subcutaneous injection of drugs in humans and animals. The concentration used for subcutaneous implants is about 50 %, but we have found severe local irritation when injecting 10-18 % NMP (Pharmasolve) by the subcutaneous route in mice. Have any of you had such experience? Any hint to solve the problem? Thanks in advance.
Sergio
Hello. I have never injected NMP in animals and never used it to formulate drugs. But given that the material is a know skin irritant, it's not surprising that some mice react adversely to it. It's also a class 2 residual solvent per ICH (understand, medium toxicity, quantities must be controlled and reported).
Publicly available SDS from Sigma-Aldrich, Product# 328634, Cas# 872-50-4
H227 Combustible liquid.
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.
H360 May damage fertility or the unborn child.
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