In partial hepatectomy models, fat accumulation occurs during hepatocyte regeneration. Whether it is needed is controversial. Though it was initially thought to be the "fuel", later experiments have shown that proliferation can proceed even if fat accumulation is disrupted. My question is, what triggers this accumulation and what is its function.
Thank you
Hello Ajit Venniyoor
Hepatic lipid accumulation after partial hepatectomy is a consequence of enhanced fatty acid mobilization and metastasis to the liver, as well as increased hepatic lipogenesis and decreased secretion of very-low-density lipoprotein.
It is proposed that due to increased energy demand for cell proliferation and for enhanced biosynthesis of membrane phospholipids during liver regeneration, hepatic lipid accumulation takes place.
The investigators in the paper attached below strongly suggest that this event is required for hepatic regenerative response because it is linked with each major wave of hepatic proliferation. They found that the three waves of hepatic fat accumulation occurred during partial hepatectomy-induced liver regeneration. These three waves are coupled with the first three rounds of hepatic replication.
Please refer to the article attached for more information.
Article Four Waves of Hepatocyte Proliferation Linked with Three Wav...
Best.
Thank you Malcome Nobre for your reply. I am aware of this paper but there are others where fat accumulation was disrupted and yet proliferation continued. My more specific question is, which are the cytokines involved in triggering this accumulation. Thank you
Hepatic lipid accumulation after partial hepatectomy is a consequence of enhanced fatty acid mobilization and metastasis to the liver, as well as increased hepatic lipogenesis and decreased secretion of very-low-density lipoprotein.
Thank you Dr Faris. My more specific question is, which are the cytokines involved in triggering this accumulation and to what purpose?
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