If I have the same liposomes of two different sizes, i.e. 200 nm vs 1000 nm, but the composition is the same, both of them should have the same zeta potential? Thanks.
Depends on the velocity zeta potential will vary, smaller particle has high velocity , hence based on size potential will vary...
it meant surface area and charge of particle affect the zeta potential, tiny particles has more surface energy so potential may vary depends on size, size of particle measured by velocity so i said depends on velocity potential may vary @Paolo Trucillo
Z potential depends on several aspects you should consider:
The surface of the nanoparticle
The fraction of polarized surface.
The concentration of nano-system.
The dispersion medium conditions, such as pH, ionic strength and additives of opposite charge.
In your specific case, you must set variables, so you can do a comparison on the size; As this parameter is related to the surface to have each liposome. Therefore, you must be very careful with concentration, because to liposomes (larger sizes) will exist fewer nanosystems than the smaller sizes liposomes. Besides, yo must check the correlograms and photon counting. In addition, the potential z is strongly influenced by the system viscosity, so you should verify that the samples do not exist a marked differences with such parameter.
Finally, if you have all this set ...so you should expect a greater potential z in liposomes smaller.
We have different liposomes but the composition is the same (only varies the active encapsulated into the membrane). pH, ionic strength and concentrarion are the same. But if we have the same liposomes but of different sizes, the z potential should vary? Normally, if it's the same concentration, but different sizes, the counting should be different because smaller liposomes would count, as number, larger than larger liposomes since they, as number, should count less. In volume, is different, smaller liposomes occupy less volume than larger liposomes. Viscosity is low, but turbidy and coloration are present in the dispersion. I'm going to set variables to make a good comparison. Thanks.
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