In many regions of the world, women have little or no authority or independence and are not in a position to demand safe sexual practices such as the use of barrier contraceptives. There is a great need, therefore, to identify methodologies that can be used discretely by women to prevent HIV transmission. An enhanced understanding of the factors that facilitate or retard male-to-female HIV transmission would enable the design and development of effective anti-HIV strategies. Many studies have shown A lactobacillus-dominant vaginal microbiota has been shown to decrease heterosexual HIV transmission. Others say that it doesn´t. Whats your opinion?
Lactobacillus is a Probiotic Medicine . It is very nicely control the essential bacterial concentration at colon . Which increases immunity power in terms of
de accelerating HIV .
Certain species of LAB are reported to have Anti-viral activity as the following publications
Antiviral potential of lactic acid bacteria and their bacteriocins
Antiviral activity of new food probiotic product in vitro
As food microbiologist dealing with virus is far from the scope of our work but is possible to be explored and is worth to be explored
currently, we are using LAB as antifungal and antibacterial, they key success of these LAB is the production of peptides as in the following papers, peptides are reported to have antiviral activity, so if you linked the production of peptides by LAB and the antiviral activity of some peptides you can conclude the potential to use LAB and their peptides to prevent HIV
some selected publications
Novel Antifungal Peptides Produced by Leuconostoc mesenteroides DU15 Effectively Inhibit Growth of Aspergillus niger
Identification of antifungal peptides produced by Lactobacillus
plantarum IS10 grown in the MRS broth
In vitro antiviral activity of antimicrobial peptides against herpes simplex virus 1, adenovirus, and rotavirus
Antiviral activities of peptide-based covalent inhibitors of the Enterovirus 71 3C protease
Antiviral activity of animal venom peptides and related compounds
Antiviral activity of α-helical stapled peptides designed from the HIV-1 capsid dimerization domain
Regards
Belal J. Muhialdin, PhD
I studied the role of vaginal lactobacilli isolated from healthy women in human cervico-vaginal and tonsillar tissues ex vivo, it was published recently.
Vaginal Lactobacillus Inhibits HIV-1 Replication in Human Tissues Ex Vivo
https://doi.org/10.3389/fmicb.2017.00906
Just to summarize, I observed a clear inhibition of HIV-1 replication by lactobacilli in human tissues ex vivo trough multiple mechanisms.
Best
Rogers
This is very interesting question. Look, lactobacilli,enterococci and some other lactic acid bacteria produce lactic acid which acidifies the environment,produce diacetyl,carbon dioxide, ethanole,acetaldhyde, classical antibiotics and bacteriocins or antimicrobial protein. All of these substances could make unsuitable environment for HIV replication. It is not clear to answer delicately in clear approve about the mechanism.Further studies are necessary to show whether metabolites of probiotics in vivo are used as nucleoside analoges to decrease viral replication or no.It is approved scientifically that vaginal probiotics inhibit vaginal pathogens and there is an inverse relationship between both of them
It appears so, further studies are needed.
Check http://onlinelibrary.wiley.com/doi/10.1111/1574-6976.12029/full. It may be helpful.
Yes. Please take a look at the following references.
Article HIV Inhibition by Lactobacilli: Easier in a Test Tube Than i...
Article Inhibition of HIV infectivity by a natural human isolate of ...
Article Vaginal Lactobacillus Inhibits HIV-1 Replication in Human Ti...
Article Probiotics: Potential to Prevent HIV and Sexually Transmitte...
Lactobacillus is a Probiotic Medicine . It is very nicely control the essential bacterial concentration at colon . Which increases immunity power in terms of
de accelerating HIV .
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