Hello Atta Alsarray , take a look at these publications. They may be useful to you;

Wu, Y., Xu, X., Chen, Z., Duan, J., Hashimoto, K., Yang, L., Liu, C., & Yang, C. (2020). Nervous system involvement after infection with COVID-19 and other coronaviruses. Brain, behavior, and immunity, 87, 18–22. https://doi.org/10.1016/j.bbi.2020.03.031

COVID-19 and the central nervous system. 10.1016/j.clineuro.2020.106116

Hello Atta Alsarray

Please refer to the research articles given below for more information.

https://www.nature.com/articles/s41582-020-00453-w

https://www.nature.com/articles/s41593-020-00758-5

Article Effects of COVID-19 on the nervous system

Best Wishes.

Thanks so much for your answers and comments

yes, because this virus causes loss of olfactory and taste.

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Also, see the following RG link and attached document.

Article SARS-CoV-2, an Underestimated Pathogen of the Nervous System

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Yes, It does. There's an involvement of CNS also in people JUST vaccinated. Unbelievable

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Yes. There's an involvement in a few cases of PNS at the lower limbs.

In my experience two cases of cubital tunnel syndrom after ICU intubation. Not sure If It is due only to the position.

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Please also have a look at the following RG links.

Article SARS-CoV-2 Infection in the Central and Peripheral Nervous S...

Article Neurobiology of SARS-CoV-2 interactions with the peripheral ...

Article Infection Mechanism of SARS-COV-2 and Its Implication on the...

Article Neuroinvasive potential of SARS‐CoV2 with neuroradiological ...

Contrasting evidence suggests that SARS-CoV-2 may not directly enter olfactory sensory neurons, but instead may target sustentacular, mucosal cells, Bowman's cells and olfactory stem cells in the human olfactory epithelium

Although there have been no dedicated mechanistic studies thus far looking at how the SARS-CoV-2 virus might directly impact nociceptive hypersensitivity, the extensive, systemic hyperinflammation seen in severe COVID-19 has the potential to contribute to nociceptor sensitization. Through secondary analyses of publicly available RNA-seq data sets, we have identified several secreted ligands that have the potential to modulate sensory neurons in humans after severe COVID-19 infection. It remains unclear, however, whether the mechanism(s) of neuronal sensitization in severe COVID-19 are the same as those in milder cases, given that both the nature and extent of immune response in COVID-19 can be significantly different depending on infection severity. The impact of cytokine storm must also be considered as a potential driving factor for the development of neuropathies after severe infection and could contribute to the development of chronic pain after acute COVID-19 infection has resolved.

COVID-19 infection has resolved. Continued research into the mechanisms of SARS-CoV-2 neurovirulence, including whether direct neuronal infection is possible, will be essential to not only help us understand how this pathogen acutely impacts neuronal hypersensitivity but also whether this is dictated by infection severity, and how these neuronal changes might contribute to COVID-19 survivors experiencing painful sequelae in the long term.

The two new studies provide the first look at how SARS-CoV-2 could interact directly with sensory neurons, or even infect them, if not definitively showing that they do so. But even if the virus is only a robber with a drill outside the bank, it appears capable of causing plenty of disruption to neurons, and plenty of resulting symptoms.

Unfortunately, it is unclear if the neurological symptoms of COVID-19 result from cytokine storm-induced neuroinflammation or some brain areas’ infection. Nevertheless, the CNS and immune system involvement might have remarkably neurologic long-term consequences, including the development of neuropsychiatric disorders. Therefore, the awareness of the CNS invasion pathways, the degree of CNS and PNS involvement, and the time course of the viral spreads throughout the nervous system will help comprehend the pathological consequences better and improve the treatment’s diagnostic criteria of possible neurological sequelae.

Yes, SARS-CoV-2 has been detected in olfactory neurons and olfactory transmucosal spread has been described (1-2).

This may explain the smell disturbances as a feature of COVID-19.

1. Article SARS-CoV-2 detected in olfactory neurons

2. Article Olfactory transmucosal SARS-CoV-2 invasion as a port of cent...

Hi Dr Atta Alsarray . Contrasting evidence suggests that SARS-CoV-2 may not directly enter olfactory sensory neurons, but instead may target sustentacular, mucosal cells, Bowman's cells and olfactory stem cells in the human olfactory epithelium (Brann et al., 2020). See the link: Article SARS-CoV-2 and nervous system: From pathogenesis to clinical...

However, COVID-19 itself can lead to neurological and mental complications, such as delirium, agitation, and stroke. People with pre-existing mental, neurological or substance use disorders are also more vulnerable to SARS-CoV-2 infection ̶ they may stand a higher risk of severe outcomes and even death. See the link: https://www.who.int/news/item/05-10-2020-covid-19-disrupting-mental-health-services-in-most-countries-who-survey

Kindly, see the following link too: https://www.painresearchforum.org/news/155784-sars-cov-2-interacts-sensory-neurons

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Severe Acute Respiratory Syndrome Coronavirus 2 Infects and Damages the Mature and Immature Olfactory Sensory Neurons of Hamsters. https://pubmed.ncbi.nlm.nih.gov/32667973/

Check https://www.frontiersin.org/articles/10.3389/fnana.2020.00037/full

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Yes it does.

Contrasting evidence suggests that SARS-CoV-2 may not directly enter olfactory sensory neurons, but instead may target sustentacular, mucosal cells, Bowman's cells and olfactory stem cells in the human olfactory epithelium

Thanks for your answer

Yes, absolutely. Recent anecdotal and scientific reports have provided evidence of a link between COVID-19 and chemosensory impairments such as anosmia.

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Many of the symptoms experienced by people infected with SARS-CoV-2 involve the nervous system. Patients complain of headaches, muscle and joint pain, fatigue and “brain fog,” or loss of taste and smell—all of which can last from weeks to months after infection. In severe cases, COVID-19 can also lead to encephalitis or stroke. The virus has undeniable neurological effects.

https://www.scientificamerican.com/article/what-we-know-so-far-about-how-covid-affects-the-nervous-system/