Does homogenetisic acid have cytotoxic properties?

Subramaniyan Bharathiraja @Subramaniyan-Bharathiraja

06 December 2013 1 3K Report

Homogenetisic acid from strawberry tree honey has been reported for antioxidant activity. Also its an intermediate metabolism in tyrosine degradation. Its accumulation can cause alkaptonuria.

Brian Lee

There are two CAS# listings. 451-13-8 and 102-32-9. One is the 3,4 and the other is the 2,5 dihydroxy-. I don't think there has been much toxicity testing on it. I did find a citation of a simple cytotox in vitro test and an amusing article about an alkaptuonuria patient who had his b&w photo developed in his own urine. Note similarity of structure to hydroquinone which is in regular developer.

http://www.ncbi.nlm.nih.gov/pubmed/21834238

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC556036/

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