Dear Researchers ....
Need help for COVID 19 drug discovery. Recently, COVID-19 main protease crystal structure was deposited in the protein database (PDB ID: 6LU7 https:/www.rcsb.org/structure/6LU7) to discover a coronavirus drug. I have enough information to design and synthesize a potential drug (without toxicity) against coronavirus (COVID 19) using a structure-based drug design approach based on COVID-19 protein data. This is the preliminary study, and it will assist in further drug development and discover the process of challenging coronavirus. But I have no idea, in the In-vitro process (COVID 19 inhibitory activity), to test synthesized compounds. I would, therefore, like to ask everyone who is a professional in this area to send your suggestions here or to contact me for collaboration research.
Designing inhibitor against host Receptor (probably ACE2) may be effective strategy to inhibit attachment of this virus with host.
Recently a group has predicted its Receptor as ACE2 that may be experimental proved before designing inhibitor.
https://www.nature.com/articles/s41421-020-0147-1?fbclid=IwAR0j5YQz364x152jwO11KdmspFskxJrFTCun4zdP2y3vhrSgpCtI1CrgbTw
I believe that there are no COVID 19 specific enzymes that can be targeted
Dear Prof. Zeyad T. Al-Rassam Please refer to this link https://www.rcsb.org/structure/6LU7
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