Autophagy is a self-eating process, the concept of autophagy in cancer is clearly determined. But if this autophagy signaling pathway goes wrong does it play any type of deformity like an autoimmune disease?
Hello Muhammad Fozan
The interplay between autophagy and the immune system emphasizes an important role of autophagy in the pathogenesis of autoimmune diseases. In both in vivo and in vitro systems, inhibition of autophagy ameliorates diseases including SLE, MS, and RA, and in other cases, it seems to exacerbate diseases such as psoriasis, psoriatic arthritis, and IBD.
In addition, the regulation of autophagy varies in different tissues and cells. This evidence means that extreme care should be exercised if autophagy is to be utilized as a therapeutic target. Individual differences, even in the same types of diseases, should be considered.
If you consider SLE, for instance, SLE is a heterogeneous disease, and lupus patients might be either predominated by IL-17a and/or IL-21 expression. The outcome might be totally different if autophagy inhibition is applied in these two different types of patients. Therefore, further investigation is needed to clarify the regulation of autophagy in each autoimmune disease, and therefore personalized therapy is strongly recommended.
You may refer to the articles attached below for more information.
Article The Therapeutic and Pathogenic Role of Autophagy in Autoimmu...
Article Role of autophagy in immunity and autoimmunity, with a speci...
Best.
Muhammad Fozan, isn't it shocking how little in this context the indispensable physiological role of the "autophagy" of the higher organisms' scavenger cells is taken into account?
As once splendidly exposed in Hans Cottier's (Bern, Switzerland) book on pathophysiology?
Where are the normal, usual, typical, standard roles of scavenging cellular activities clearly, and duly discriminated from the all too readily incriminated pathogenic ones?