We have a young man who have both T1DM and polycystic kidney disease.
His mothey have polycystic kidney disease and his father has diabetes mellitus.
He developed end-stage kidney disease. He underwent a pre-emptivecombined pancreatic and kidney transplant.
Did anyone come across a patient having concurrent T1DM and polycystic kidney disease?
I have come across patients with adult polycystic kidney disease and type 2 diabetes mellitus (as these are both common and occur in adult life) either before or after kidney transplantation and have been described in literature as well (1-2)
However, the childhood variety of polycystic kidney disease (autosomal recessive) and type 1 diabetes are both rare and fatal during childhood . I have not come across such cases myself or in the literature.
A practice point:
When a genetic disease has inheritance both as autosomal dominant and autosomal recessive, autosomal recessive is rare, very severe, and has poor prognosis: Examples being polycystic kidney disease, Crigglat-Najjar syndrome, and Icthyosis.
1. Article The impact of type II diabetes mellitus in patients with aut...
2. Article Polycystic kidney disease as a risk factor for post-transpla...
Thank you, Muhammad.
Yes, the prevalence of diabetes increases with age increases as significant number of subjects with ADPKD database are children and young adults.
Similarly, the incidence of transplant-unrelated diabetes increases among ADPKD registry , as shown in A Polish study.
However, we are discussing the TIDM co-existance with polycystic kidney disease at 20 years of age.
yes and the boy exhibit features of genetic imprinting. in this case he has renal failure earlier than the mother who has polycystic kidney disease
Issa salmi@ only one patient i got whose mother also has polycystic kidney disease. Here genetic test is not so much available and so expensive. I think there might be more cases but due to lack of investigation facilities we couldnt ruled out. Take care
1 day ago
Issa salmi@ only one patient i got whose mother also has polycystic kidney disease. Here genetic test is not so much available and so expensive. I think there might be more cases but due to lack of investigation facilities we couldnt ruled out. Take care@Issa salmi
Thank you. I would have been intresting to have the whole geneome sequence/testing but limitations are always there.
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