various invo medels are available for example

Torcetrapib produces endothelial dysfunction model in rabit. You can check same in Apo E mice and obviously develop a new model on mice.

One refence is thier you cna go threw it.

http://www.ncbi.nlm.nih.gov/pubmed/20051879

Thank you so much, Doctor Tirgar!

I'll think about it!

I`ve read about surgical infliction of aortic intimal injury (using a baloon-tipped catheter) in rabbit models prior to atherosclerosis experiments but I dont think it would work about mice due to their small size. That`s the most commen way I think

check this out Gianne