Kendomycin is an antibiotic produced by Streptomyces spp. and was produced firstly by S. violaceocolor.It has antibacterial activity against Gram positive and Gram negative bacteria , MRSA strains.Also it showed anti-cancer activity against cancer cell line. I would like to know wheather it has antifungal activity or no.Please support yr answer by a reference.
Article Investigations to the Antibacterial Mechanism of Action of Kendomycin
Regards
Here is one:
Yasser A. Elnakady, Indranil Chatterjee, Markus Bischoff, Manfred Rohde, Michaele Josten, Hans-Georg Sahl, Mathias Herrmann, and Rolf Müller (2016) Investigations to the Antibacterial Mechanism of Action of Kendomycin. Plos one DOI: 10.1371/journal.pone.0146165.
After careful reading you will understand why you do not find any report on antifungal activity of Kendomycin.
Thank you my colleague.I have this paper and agree with it that mode of action of kendomycin has yet to be defined.Kendomycin treated bacterial cell displayed incomplete septa with abnormal morphology and hence kedomycin affect the cell division machinery and protein stability.Such explanation was applicable on bacterial cells.Fungal cells have certain specific conditions such as cell wall structure and ribosome size even there are some similarities. I have approvrd work on antidermatophytic activity of one kindomycin derivative produced by one streptomycetes isolate. I was asking to support such result.Of course it needs more studies,but we can not make everything in one article.
Article Investigations to the Antibacterial Mechanism of Action of Kendomycin
Regards
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