Hi there,

Article Toward Small-Molecule Inhibition of Protein–Protein Interact...

One example: Nutlin-3 disruptes the interaction of the tumor suppressor p53 and its antagonist Mdm2.

There are lot of exmaples:

• HIV-1 gp120/CD4 interaction: The interaction between the HIV-1 envelope glycoprotein gp120 and the CD4 receptor on T cells is essential for viral entry into host cells. Small molecule inhibitors of this interaction, such as maraviroc, have been developed as HIV/AIDS therapeutics
• NF-kappaB/p50:p65 interaction: The interaction between the transcription factor NF-kappaB and its p50:p65 heterodimer is important for regulating gene expression in response to inflammation and other stimuli. Small molecule inhibitors of this interaction, such as IMD-0354, have been developed as anti-inflammatory agents.

Article Elucidation of protein interactions necessary for the mainte...

Figure 1 shows Imatinib disrupts the protein-protein interactions of Bcr-Abl with some, but not all interaction partners.