I haven't found any evidence regarding the duration of botulinum toxin effects in athletes! In my clinical experience, it tends to last less...
Chris Blatchley
Only a very small proportion of the BoTn/A is absorbed into the nerve endings as the vesicles that contain the neuro-transmitter are reincorporated into the synaptic plate The rest is washed away into the circulation where it is removed by the liver, so there is no free toxin in the body within a few hours (one of the reasons why immunity to toxin from therapeutic treatment is very rare) So few molecules of short chain toxin are present within each neuron that it is thought that it is acting catalytically Clinically, people report that the effect of the toxin remains active fairly constantly for about 3 months when its efficacy falls away quickly. People report that they notice muscle movement returning over only a day or two. It is certainly true that the period of efficacy is quite variable. It also appears true that sometimes the toxin does not 'take' properly. As yet, to my understanding there is no explanation how/why this happens I look forward to hearing other researchers' observations
Although I don't have an answer for you, I suspect that the answer is no.
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Ana Cristina Diniz Silva
Thanks for your comprehensive answer! I agree with items 4 and 5, and such observations may be regardless frequent or intense physical activity.
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Ana Cristina Diniz Silva
Hi Dr Jost, that's an anecdotal observation in my clinical practice, as I have been noticing hat professional athletes come back for toxin application in an yearly frequency almost twice higher than non-athletes. I wonder whether there is any evidence in this regard...
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