If you prepare drug-loaded nanoparticles but only obtain microparticles (~2,000-4,000 nm), PDI~0.2, how can you reduce the size to reach ~100 nm?
Use a nanomill.
e.g., https://grinding.netzsch.com/en/products-and-solutions/wet-grinding/netzsch-delta-vita
If your formulation is in suspension form, you can use size reducing techniques like High pressure homogenisation or microfluidic techniques for size reduction. This method will be the scalable, reproducible and standardized methods. The selection of nozzle and other equipment parts are dependents on your material and sample. Please refer the equipment experts opinions.
Yes with the help of high speed homogeniser, Probe type solicitor and many more go for literature
They simply need some surfactant and high energy during fabrication of nanoparticles to avoid growth of large particles.
But if it's already prepared so microparticles can subjected to some size reduction process like if grinding or milling, as also mentioned above
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