16 Questions 102 Answers 0 Followers
Questions related from Chris Blatchley
It is well established that placebo response to treatments for pain (eg migraine treatments) can last a considerable time and can make it difficult to separate true effect and placebo effect....
31 August 2017 3,925 3 View
This question has arisen from contributor Pete Batcheller, who added a response to my question "Is Botox an effective treatment for Episodic Migraines?". Mr Batcheller is a very dedicated...
24 April 2017 2,146 4 View
The published research on Botox for Migraines generally suggests that it only works for Chronic and not Episodic Migraines. However this is not my experience, and it does not fit with the history...
12 April 2017 1,750 5 View
The effects of Daith ear piercings on migraines was first noticed by chance. After Dr Thomas Cohn a respected pain physician in the USA noted on his blog in March 2015 that people were reporting...
06 April 2017 5,932 8 View
5alphareductase (5ARase) inhibitors such as Finasteride and Dutasteride block the intracellular conversion of testosterone to dihydrotestosterone (DHT), and they have both been shown to reduce...
30 May 2016 245 1 View
It is well established that oral finasteride (as Propecia with 1mg dose) can help prevent male pattern hair loss by blocking intracellular conversion of testosterone to DHT by 5alpha reductase....
16 May 2016 3,057 2 View
I am interested to know whether the forces that cause brownian motion can help keep larger particle suspended in a fluid even though they are too large to show the movement.
30 September 2015 5,145 3 View
Brownian motion can be see in starch grains that are approx 1micrometre in diameter. What is the maximum size of particle before they can no longer exhibit Brownian Motion? Platelets are 2...
29 September 2015 2,737 4 View
The fluid in question is plasma and the particles are red cells (RBCs) and platelets which have a difference in particle volume of 10:1 - RBCs are a little denser than platelets and both are only...
09 September 2015 6,437 14 View
I am researching the optimal speed/duration when preparing autologous PRP. The PRP is for immediate reinjection in the clinical setting. I am finding that the supernatant platelet concentration is...
08 September 2015 4,610 15 View
I am researching the optimum centrifuge speed/time when preparing PRP for immediate autologous PRP reinjection, and have found an unexpected increase in the supernatant plasma platelet...
12 August 2015 9,947 8 View
When preparing Platelet Rich Plasma the commonest anticoagulant is Citrate. ACD-A is better at preserving the platelets unactivated at 6 hours but autologous PRP is usually administered within an...
28 April 2015 8,268 31 View
Activating Platelets with Thrombin results in a strong activation with 90% of the platelet factor payload being released within 60 mins. The platelets then continue to live for about 8-10 days and...
28 April 2015 3,093 5 View
Usually the mixture in most tubes is in the region of 1ml 3.8% citrate is addred to an 8ml tubes but this standard amount originates from the amount used in transfusion bags where the blood has to...
10 January 2015 6,617 23 View
3.8% citrate chelates Calcium less than EDTA. One can use 0.5ml citrate in 8ml to get adequate anticoagulation rather than the usual 1.0ml resulting in less dilution and less calcium that needs to...
10 January 2015 4,568 17 View
There are many kits for preparing PRP (Platelet Rich Plasma) but there is no standard speed for centrifuging the blood samples. Indeed I was looking for published research on the platelet...
25 July 2014 722 6 View
