I would like to quantify nuclear DNA content in cultured cells for the purpose of identifying copy number changes over time. I don’t need to know specifics of which chromosomes are duplicated or deleted; that will come later if I see any differences in this initial study. I cannot do flow cytometry as I will only be dealing with a maximum of 20-50 cells. The cells can be grown and fixed on a microscope slide. Any recommendations or comments are appreciated!