How do I refine a specific region of my protein model so that it perfectly superposes with a template peptide PDB with the same sequence?

I have a protein model and want to replace a 12-amino acids-long region within the center of the model with those of a PDB file containing a 12-amino acids long peptide of the same sequence. This...

02 February 2021 779 2 View

How do we modify displacement boundary conditions while using symmetry?

I'm trying to model a tensile test in ANSYS on a dog bone specimen with one end fixed and a displacement of 5 mm given to the other end. To reduce the computational memory (model has a lot of...

01 January 2020 8,904 5 View

Simulating Raman scattering using comsol?

I want to simulate a very basic Raman scattering experiment using comsol. I shine a light on the material, dipoles oscillate and re-radiate. Can anyone help me with the basic steps involved? I...

31 July 2019 1,036 1 View

Does the peaks at 1767 cm-1 and 1579 cm-1 in IR spectrum indicate the formation of glycolate or glyoxylate in the product?

Hi! I have an IR spectrum of product obtained from CO2 electroreduction in acetonitrile using sacrificial Zn anode. The product formed is normally zinc oxalate. However, at high current densities,...

31 May 2019 7,268 3 View

How to measure water temperature in thin tube with high accuracy?

I am seeking a low cost solution to measure temperature of water in a steel tube of dia 5mm for temperature range 30 - 100 C with an accuracy of 0.1 C. Any suggestions would be appreciated.

03 December 2018 755 4 View

Like Trees of Delhi which gives easy keys for tree identification in Delhi is there any book of similar kind for Uttarakhand State flora ?

15 April 2017 5,515 8 View

How can I studies the reaction path of a complex by Gaussian 09 ?

02 February 2016 1,597 3 View

What would be the advantages and disadvantages of using Dynamic Time slicing concept for scheduling?

Round robin techniques is one of the most popular scheduling algorithms but the problem with that is more context switches, more waiting time. And yes the response time is good in this case. But...

24 August 2013 2,962 2 View

Protein-aptamer gel electrophoresis help, please??

Hi, I have problems with running gel electrophoresis. I have tried agarose gel electrophoresis and native PAGE. I have two proteins, which have molecular weights of ~30kDa and ~180kDa and two...

03 March 2021 4,275 4 View

What is the method of removing RNase contamination from a filter paper surface?

I am working on a biosensing project on paper substrate, however, it is found that the RNase contamination occurs on the filter paper. Might I ask is there any method to clean the paper surface...

12 February 2021 3,926 3 View

How to find a particular aptamer complementary sequence?

I can find several papers that give me a guide for choosing a suitable aptamer sequence 1. But how to find a property aptamer sequence 2(partially complementary to sequence 1)?

09 February 2021 3,511 1 View

How to apply graphene oxide on an gold electrode?

Dear Fellows, now it is the time to push graphene applications further in terms of easy and low cost production surroundings. Thus I recently dived in the materia and I am facing tons of papers,...

02 February 2021 6,284 2 View

Why sometimes current- voltage plot in chemiresistors/ FET does not pass through the origin?

I am trying to measure resistance from I-V curve from a chemiresistor/ FET sensor with a keithly sourcemeter. The substrate is soaked/ wet with protein and phosphate buffer only. But the I-V line...

24 January 2021 8,009 3 View

Why there are fewer aptamer-based biosensors and bioassays in commercialization?

Despite the fact of the tremendous number of research papers in the literature dealing with the usage of aptamers as molecular probes in biosensing, and despite the fact that this technology is...

26 November 2020 1,140 3 View

Carbon allotrope based nanomaterials for virus imaging?

I would like to know if any carbon allotrope based nanomaterials (such as fullerenes, nanotubes, graphene, reduced graphene, graphene oxide, nanohorns, nanoonions, graphene quantum dots, carbon...

08 November 2020 5,887 3 View

Biotech Startup Research?

26 October 2020 9,698 5 View

How can I calculate the biosensing response from a chemiresistor based biosensor?

For a range of concentrations of protein, I am getting the I-V (Current-voltage) data from a Keithley sourcemeter. Accordingly, I am getting the resistance as the response of protein-protein...

03 October 2020 8,410 2 View

Can I design an aptamer that can sense microbial activity?

I am trying to design a boron nitride based biosensor that can sense the abnormality of microbial activities on fish skin. I am very curious that is it possible to have such an aptamer that can...

23 September 2020 6,352 4 View