I synthesized above polymer and tried to incorporate FAM labeled aptamer to that without any chemical conjugation. then I checked fluorescent count in supernatant and the precipitate . And also I used without polymer as a positive control. Only Fam labeled aptamer. But when comparing those I understood that almost all aptamer went to supernatant. Did anyone try to encapsulate aptamer to PLGa . can anyone suggests a way to encapsulate aptamer to PLGa with out chemical conjugation?