I'm trying to improve the solubility of curcumin (a plant extract) for an experiment by creating an inclusion complex using Hydroxypropyl-β-cyclodextrin.
I have decided to create the complex using a magnetically stirred physical mixture of distilled water, Hydroxypropyl-β-cyclodextrin, and curcumin at 50 Celsius. I will then add acetic acid to bring the PH to 3 as this seems to be PH/temperature that creates the strongest complex in studies.
My question:
How strong is the cyclodextrin complex? I am thinking of using a low temp dehydrator to dry the mixed solution, and then a grinder to create powder. Will this destroy the complex significantly - and if so how can I preserve the inclusion complex while creating a powder?
You need to pay attention to the physical form of your turkesterone, either remaining in a complex or precipitating from the complex by drying. This means the complex is stable in the former structure but not in the latter. It is least likely phase separation could occur by grinding.
Hi Kate,
You can try to lyophilize the solution .The lyophilized power may not be free flowing, but simple vertexing of the powder can help in deagglomerating and enhancing the flow. In this way you can avoid phase separation by grinding.
Hope this helps.
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