I wish to edit a portion of a gene in a cell line using HDR. The closest PAM site (TGG) on the 5'->3' strand from databases is > 10 bp from the desired sequence i wish to edit, which I've been told isn't great. However, the opposite strand has a PAM site (AGG) that is just a bit closer. I'm wondering if I should instead design my Cas9 cut there. Does having the PAM cut before the edit site matter? The replacement oligo will span many bases before and after my edit anyways.

5'->3' Sequence from database:

xxxxEDITxxxxxxxCCTTGGxxxx

5'->3' Reverse Compliment:

CCAAGGxxxxxxxEDITxxxxxxxx