As a pharmacologist and pharmacist I have been thinking about these mRNA vaccines quite a lot. In a previous discussion I asked if the mRNA sequence of the vaccines has been published. So far no answer. I ask this partly because the spike protein could theoretically alter blood pressure on its own by affecting ACE2. Firstly, does anyone here know if the mRNA encodes an entire subunit of the spike protein, or just a small antigen? Secondly, is blood pressure being monitored in any trials for the vaccine over several weeks?
- mRNA vaccines contain material from the virus that causes COVID-19 that gives our cells instructions for how to make a harmless protein that is unique to the virus. After our cells make copies of the protein, they destroy the genetic material from the vaccine. Our bodies recognize that the protein should not be there and build T-lymphocytes and B-lymphocytes that will remember how to fight the virus that causes COVID-19 if we are infected in the future.
- Protein subunit vaccines include harmless pieces (proteins) of the virus that cause COVID-19 instead of the entire germ. Once vaccinated, our immune system recognizes that the proteins don’t belong in the body and begins making T-lymphocytes and antibodies. If we are ever infected in the future, memory cells will recognize and fight the virus. [ references: CDC report/Understanding How COVID-19 Vaccines Work/Updated Jan. 13, 2021]
- Regarding your first question, I, like you, have not yet been able to find accurate information about the sequences used in the vaccine in the databases, and I would be happy if you could share your next information in this field with me.Regarding your last question, which deals with the side effect of the vaccine on the blood pressure of people who have received the vaccine, my personal advice is that it should be studied after the statistical population is treated and after a period of time commensurate with the full effect of the vaccine. Statistical study in several stages to achieve citation-able results. @Alireza Salimi
I know for the Pfizer vaccine, it contains the genetic sequence of the spike, but it also has proline mutations in a few spots. Regarding the vaccine and blood pressure, I couldn’t find any scientific papers regarding those two things. I also don’t recall seeing anything on monitoring blood pressure in the articles about each vaccine clinical trial. That’s a good question.
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