Recent research in cognitive neuroscience shows that the dopaminergic neurotransmission is correlated to creativity (both to the genesis of creative ideas and their elaboration). However, a direct stimulation of the dopaminergic neurotransmission is risky due to side-effects and an eventual blockade of creativity (and cognitive function in general).

Stimulation with psychedelics could provide some increase in creativity, but in larger doses it is also risky (due to e. .g. psychosis, loss of touch with reality, blockage of thought). The exception of the psychedelic 2-CB could provide an alternative (no 5-HT1A agonism). In this vein, it seems that the agonism at 5-HT2A receptors by 2-CB could enhance creativity safely (in moderate doses).

Therefore, can one assert that coffee (not only caffeine) can act in a similar way to 2-CB and in fact enhance creativity (by potentiating glutamatergic neurotransmission)?

Both coffee and 2-CB share the following characteristics required for creativity: an increase of associations and an increase of visual/conceptual acuity (a prerequisite for the gathering of the building blocks/details needed for the associations of ideas/images).