On one hand, exosomes have emerged as suitable nanoplatforms for therapeutic compounds delivery to cells; On the other hand, cell membrane-derived nanovesicles are biomimetic liposomes derived from source cell membranes via extrusion process and can coat nanoparticle cores or used isolated. Once both have origin on cell membranes, can we expect differences on the suitability of each type of nanosystem?
Hi,
Depends on the application.
Have a look at these highly-cited literature:
Engineering hybrid exosomes by membrane fusion with liposomes
- Yuko T. Sato,
- Kaori Umezaki,
- Shinichi Sawada,
- Sada-atsu Mukai,
- Yoshihiro Sasaki,
- Naozumi Harada,
- Hiroshi Shiku &
- Kazunari Akiyoshi
Scientific Reports volume 6, Article number: 21933 (2016)
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Comparison of exosome-mimicking liposomes with conventional liposomes for intracellular delivery of siRNA
Author links open overlay panel Mei Lu et al.
Article Comparison of exosome-mimicking liposomes with conventional ...
Dear Sir, I am also working on Exosomsés derived from bovine mills. As per your question do you mean once u isolate them from cell membrane and do some nanofabrication and reintroduce it back in to body. Did they differ from the unmodified one with respective to properties? Is it your question. I think they may differ in physical-chemical properties and I am not sure about performance and it need to better study case by case I guess. R u trying to isolate exosmose by in vitro cell culture or in vívo body fluids?
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