Working hypothesis of mine: Intracellular pH and catecholamines work synergistically
The answer depends on the circumstances, one of the factors is certainly important: the pH of the insides of the cells. Namely, the intracellular pH is crucial to how catecholamines can affect. In acidotic milieu, the catecholamines have little effect, so that the catecholamine overproduction is a compensatory phenomenon which helps (e.g.) to myocardial cells to contract. That is, giving adrenergic beta-blocker can be harmful, in this case, I think. The situation is different if the intracellular pH is alkalotic, e.g., in the case of acute hypocapnia. But even in this case is the best adrenergic beta blocker which increases pCO2 to the normal level, I think.
If we read a hundred articles, 99 of them certainly state that their effects and an increase of catecholamines level are bad things. Are they right? I don't think so, it depends on….. An alkalotic cell interior, namely a sudden decrease of pCO2 level can be dangerous for an organism which has less resistant places (= tissues which have decreased ability to produce enough ATP). It may further damage these tissues, possibly endangering the life of the organism.
It follows that one aspect should undoubtedly be taken into account, the intracellular pH. However, this is not known in clinical conditions. Then we should know what is the current pCO2 (blood gas). On the other hand is pCO2 level decreasing or increasing? What does change the pCO2 levels? I hope that the followers of this project will answer this question.
I'm looking forward to the comments.
Dear Sir. Concerning your issue about the Catecholemines. Catecholamines are derived from the amino acid tyrosine, which is derived from dietary sources as well as synthesis from phenylalanine. Catecholamines are water-soluble and are 50%-bound to plasma proteins in circulation. Included among catecholamines are epinephrin (adrenaline), norepinephrine (noradrenaline), and dopamine. Release of the hormones epinephrine and norepinephrine from the adrenal medulla of the adrenal glands is part of the fight-or-flight response. Catecholamines cause general physiological changes that prepare the body for physical activity (fight-or-flight response). Some typical effects are increases in heart rate, blood pressure, blood glucose levels, and a general reaction of the sympathetic nervous system. Some drugs, like tolcapone (a central COMT-inhibitor), raise the levels of all the catecholamines. Catecholamine is secreted into urine after being broken down, and its secretion level can be measured for the diagnosis of illnesses associated with catecholamine levels in the body. Urine testing for catecholamine is used to detect pheochromocytoma. I think the following below links may help you in your analysis:
https://www.researchgate.net/topics
https://en.wikipedia.org/wiki/Catecholamine
https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/catecholamine
https://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=EN&Expert=717
Thanks
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