Dear Colleagues,
I have to start a study about a comparison between the metabolism of Human TONGUE Epithelial Cells (healthy cells) and human tongue squamous carcinoma cell line, after treatments.
I have the human tongue squamous carcinoma cell line but I need to buy Human TONGUE Epithelial Cells (healthy cells). Can you suggest a company where it is possible to find them? I am in Italy.
Thank you so much for your support
Andrea
As far as tongue is concerned, I was unable to find a common healthy cell line. There are some healthy cell lines that are derived from the oral cavity, but not particularly tongue -> Check Tables of the article:Article Cell culture models of oral mucosal barriers: A review with ...
)I believe the closest model for your study would be DOK (dysplastic oral keratinocyte), derived from a piece of dorsal tongue showing epithelial dysplasia (premalignant condition) -> https://web.expasy.org/cellosaurus/CVCL_1180. Another solution is to choose a cell line that would be phenotypically the closest to healthy tongue epithelial cells (maybe the immortalized human oral keratinocytes derived from oral mucosa/gingiva, or some other common keratinocytes or basal cells).
I agree that there does not seem to be a healthy tongue cell line. Almost all tongue derived cell lines are cancer cell lines from SCCs. However there is a cell line, D34, which is from a "less" diseased tongue, from a leukoplakia:
https://web.expasy.org/cellosaurus/CVCL_HF98
It is a cancer cell line but represent a "early oral
cancer progression" stage, so it may be more appropriate than the SCC cell lines.
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