We are an R&D laboratory focused on anionic, cationic, and zwitterionic surfactants and usually tackle surfactant synthesis and analysis of products from customers. In particular, we deal with AOS (alpha-olefin sulfonates), primary alcohol sulfates, betaines, amphoacetates, amine-oxides.. etc. To gear our analytical laboratory up, we identified an HPLC-MS (single quadrupole) instrument as a valuable addition to comply with unmet needs that have risen in the last years, like figuring out the outcome of the new reaction and investigating byproducts and new raw materials. Currently, we are evaluating three choices: Agilent LC/MSD, Waters Acquity Arc System (with Qa Acquity Detector), and Shimadzu LC-MS2050. Could anyone in this field share their experiences with these instruments? and suggest which of them is the most reliable for this application. Thank you so much for your attention and participation.