While genes are non-modifiable factors, lifestyle and environmental factors are modifiable. So it's not a case of challenging the genetic factors but working on the other factors within your circle of influence in order to possibly influence the way the genes are expressed.

You cannot alter your genom, your actual DNA chain.

But you can alter DNA methylation and in such way change the expression of the DNA. Epigenetic changes in the DNA can last and in some cases even pass to the next generation.

Read 'epigenetics' in WIKIpedia for futher explanation.

While genes are non-modifiable factors, lifestyle and environmental factors are modifiable. So it's not a case of challenging the genetic factors but working on the other factors within your circle of influence in order to possibly influence the way the genes are expressed.

No.

But expression of genetic effects can be minimised by following controlled and expert directed lifestyle.

Thanks.

I do agree with Jos.

I have diabetes because my mother was also diabetic. However; I am fine only with low carb diet and no medecine at all. It is not easy ; especially in the beguining. However diet not only solved my diabetes problem but also made my immunity system stronger. I feel much healtier now than when I had diabetes fifteen years ago.

Although it is related to the genetics of the person, however if we manage our diet and regular exercise, we can achieved the desirable weight and stay healthy, fit and happy. But the problem with the genetics is if you stop doing all the healthy activities, then it will be totally controlled by genetics and your lifestyle.

YES

i guess you can. Simply by reducing the incidence of metabolic ailments, boosting immunity and having a lot of endorphins u can have improved longevity.

There is a molecular angle to this.

Exercise increases the length of telomere part of chromosome which has been associated with longevity

Regards

Some reference

Article Role of Telomeres and Telomerase in Aging and Cancer

Article Telomeres, Aging and Exercise: Guilty by Association?

Article Telomeres, Aging and Exercise: Guilty by Association?

I hope this will help. Drugs to increase/maintain lengthof life are in phase of development. They act thru enzyme telomerase which is responsible to maintain the length of telomeres.

Exercise can also add to this length or simply maintain it

Regards

These schematic also highlights the role of exercise in increasing telomeres which are linked to longevity

this schematic better depicts the role of exercise in telomere length maintenance

Just for the record, since my reply 4 days ago was lost somehow.

You cannot change your DNA or your genome, but you can change to some extend the expression of your genome by changes in DNA methylation or by histone modification, which is called epigenetics. See WIKI 'epigenetics' .

Hence, diet or enviromental factors do not alter our genome but they may change our epigenome.

See for example https://www.whatisepigenetics.com/epigenetics-nutrition-health-eat-affect-tags-dna/

Dear@Jos

The genetics superimposed by our epigenome matter a lot and not much of difference can be there but still ongoing research is tilting towards experimental therapies are heading this way.

Exercise in some way as mentioned above does reduce the some damage and allows some extra years and telmeres can be one such thing

regards

no......but can challenge epigenetics.

Hello,

Actually you can't change the genome , but tha hope is the change of life style as early as possible in younger age specially children so you can stope epigenetic changes and gain a new healthy habitts that tramsmitted to the next generations. The change of life style is mandatory including eating healthy foods, regular exercise and physical activity, good sleep, drink water and psychological health.

I guess even if we cant help genetics, still epi-genetics can be prevented and damage can be challenged by quality life style and exercise

Following answers.

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