Hi,

I intend to give mice 150 mg/kg of pyrazinamide. I need 3.7mg per mice and 100ul needs to be administered. The drug only dissolves in DMSO and the final amount of the DMSO in water exceeds more than 25 percent of DMSO.

Did anyone try to dissolve pyrazinamide in other vehicles? I need at least 250mg/ml solubility in that solution. max solubility of pyrazinamide in DMSO is 130mg/ml.

Thanks in advance