Can we use carboxymethylcellulose (CMC) as vehicle/solvent for Intraperitoneal dosing in rat or mouse? If yes, then how much percentage of CMC is accepted for IP route of administration?
To test my newly synthesized molecules in rodents, I prepared it in 0.25% of CMC because it is not soluble in water. After toxicity study and PK study, I tested the compounds by oral route and IP route for 6 days. The IP route of administration showed greater efficacy than oral dosing.
Can I prefer the same route of administration (solvent - 0.25% CMC) for any chronic study?
does the CMC solution complex your active or does it act as dispersing agent. You should be clear about this. In the second case you have to ensure that particle size do not exceed a critical value.
Hello,
Carboxymethylcellulose (CMC) is indeed a viable option as a vehicle or solvent for intraperitoneal (IP) administration in rodents, provided it is used within appropriate concentrations and prepared correctly. CMC is commonly employed in pharmacological studies for its non-toxic, inert, and viscous properties, making it suitable for suspending insoluble compounds. Here's a detailed overview of its use:
In conclusion, carboxymethylcellulose can be an effective vehicle for IP dosing in rodents, particularly for insoluble compounds. Its use should be tailored to the specific requirements of the experiment, considering factors like concentration, preparation, and the nature of the drug being administered.
l Take a look at this protocol list; it could assist in understanding and solving the problem.
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